THE ANTI HRSV ACTIVITY OF Ferula halophila Peşmen AQUEOUS AND METHANOL EXTRACT BY MTT ASSAY

The trend towards natural products in the world is increasing due to increased drug resistance of infectious diseases, high prices for drugs and difficulty access. Also, bacterial or viral diseases that are difficult treat need a long time proper treatment cause important infections people. Since effective could not be developed most infections, it very find against viruses introduce them science. antiviral activities aqueous methanol extract from Ferula halophila Peşmen, an endemic species Turkey, has been investigated human respiratory syncytial virus (HRSV, ATCC-VR-26). cytotoxic properties plant extracts were HRSV / HEp-2 cell systems, respectively by colorimetric MTT assay. In study, titer RSV was used as 100 TCID50 (50% tissue culture infective dose). While MNTC (Maximum non-toxic concentration) 195.313 µg/mL CC50 4366.22 µg/mL, determined = 390.625 extract. According results, showed more toxicity than Ribavirin positive control 0.98 110.40 µg/mL.As result effective, whereas had significant anti-HRSV activity with values 50.69 EC50 Effective Concentration) 97.54 Selectivity Index (SI). SI 2.39 46.19, respectively.According we can explain presence only absence insolubility compounds